JackTheRipper
11 augustus 2002, 18:04
Een tijdje geleden heb ik op dit forum om advies gevraagd welke producten ik zoal kon gebruiken voor mijn terugwijkende haarlijn.
Ondertussen heb ik veel gelezen over haaruitval en de producten die er zijn om dit tegen te gaan op verschillende websites en ben ik begonnnen met de volgende behandeling: Nizoral 2% shampoo, Dr. Proctor's regrowth shampoo , 5% Xandrox (5% Minoxidil, 5% Azelaic Acid).
Sites waar je veel informatie kan vinden zijn www.regrowth.com, www.hairlosstalk.com, www.hairlosshelp.com . Als je al de informatie daar leest krijg je een goed beeld van hoe je haaruitval moet tegengaan en leer je ook dat de mate van je haaruitval genetisch voorbestemd is en niks te maken heeft met sex of bewegen of van die andere onnozele beweringen. Op www.hairlosshelp.com is er een "Ask the expert section" waar o.a. Dr. Proctor (www.drproctor.com) en Dr. Lee (www.minoxidil.com), toch wel twee autoriteiten op het gebied van haaruitval en de behandeling ervan vragen beantwoorden, als je daar een "search" doet in de reeds gestelde vragen kan je ook veel bijleren.
Om je haarverlies tegen te gaan heb je een groeistimulator nodig, de beste is Minoxidil, een andere groeistimulator is Nano, een soort natuurlijke Minoxidil ( nicotinic acid N-Oxide) en SODases (superoxide dismutases).
Er zitten SODases in de producten van Dr. Proctor en Folligen en Tricomin bevatten copper peptides.
"Oral minoxidil, a medication that originally was used to treat high blood pressure , has been found to increase hair growth. This lead to the development of topical (solution applied to the skin) minoxidil. Topical minoxidil (Rogaine) has been shown to stimulate hair growth."
"Superoxide dismutase. This is an enzyme produced by the body to neutralize the superoxide radical. Superoxide is a messenger of inflammation and is involved in the body's autoimmune response. It exists in a yin yang relationship with nitric oxide. Nitric oxide is a vasodilator that appears to be important for hair growth, while superoxide is a vasoconstrictor that may be part of the signaling mechanism that tells hair to stop growing. Superoxide can also interact with nitric oxide to form a highly destructive free radical called peroxynitrite, which causes protein and lipid oxidation. A few hair products contain copper peptides, which are SOD mimetics; i.e., mimic the effects of the body's SOD enzyme. SOD-containing products have been noted a number of times by researchers to stimulate hair growth and block hair loss in mice. Recent study data on Tricomin, a copper peptide SOD, indicates increased hair growth in MPB. Among other beneficial things, SODs appear to help spare growth-stimulating nitric oxide, reduce damaging inflammation, and help reverse fibrosis (follicular scarring). There are a few patents for SODs as hair growth stimulators and even one for an SOD inhibitor that blocks hair growth by increasing superoxide."
Om DHT tegen te gaan is het niet noodzakelijk van Finasteride te nemen. Azelaic Acid en Spironolactone die je op je scalp moet doen doen dit ook en hebben geen neveneffecten:
"Azelaic acid in Xandrox will inhibit virtually all synthesis of DHT in the scalp at the follicle level. It does this by inhibiting the synthesis of testosterone into DHT by both type 1 and type 2, 5-alpha reductase enzyme. On the other hand, Spironolactone blocks the follicular androgen receptor sites, inhibits the conversion of steroids to DHT, and converts testosterone into estrogen in the scalp. Azelaic acid cannot protect against circulating DHT. Topical spironolactone fulfills that need, but rather than reducing circulating DHT like finasteride does, it takes the place of it by blocking circulating DHT from the follicular receptor sites."
De beste shampoos die je kan gebruiken zijn Nizoral 2% shampoo en Nano shampoo van Dr. Proctor, je kan ook een "light" versie kopen van Nano shampoo, die Dr. Proctor's regrowth shampoo heet en goedkoper is bij www.anagen.net en www.lef.org
Je moet minstens 6 maanden wachten voor je resultaten kan verwachten en het beste is van een product 1 jaar te gebruiken om te zien of het echt werkt bij jou. Je moet ook realistische verwachtingen hebben, dun haar kan zogezegd "gemakkelijk" terug dikker worden maar plaatsen die al langer dan 5 jaar kaal zijn daar is het heel moeilijk om nieuw haar te laten groeien. Je moet de behandeling wel blijven volhouden want als je stopt ben je in 4 maanden al de resultaten ervan kwijt.
Ik denk dat dit de beste producten zijn:
- Nizoral 2% shampoo
- Nano shampoo, Proxiphen-N en Proxiphen zijn van Dr. Proctor (www.drproctor.com)
- 5% Xandrox of 12,5% Xandrox voor de recalcitrante plaatsen zoals de slapen en 5% Spironolactone van Dr. Lee(www.minoxidil.com)
- eventueel Folligen of Tricomin als bijkomende behandeling maar op zichzelf alleen zullen die niet veel uithalen
Hier is nog een studie van Nizoral shampoo:
Nizoral 1% Study Shows Benefits for Androgenetic Alopecia
March 04, 2001 - American Academy of Dermatology Meeting - Washington DC - Scientists working for McNeil, makers of Nizoral anti-dandruff shampoo, presented the findings of a study done on 1% Nizoral shampoo which has good news for hair loss sufferers. It has long been known that 2% prescription Nizoral has beneficial effects on Androgenic Alopecia (MPB). It however has been unclear whether the same benefits can be obtained by using the non-prescription 1% version.
In the study presented (see below), one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using, in a double-blind fashion, either a 1% Nizoral shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with Nizoral use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with Nizoral (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hair shed over a 24-hour period was reduced by 16.46% with Nizoral and 6.02% with zinc pyrithione after 6 months. Finally, the percentage hairs in anagen phase increased by 6.4% and 8.4% respectively during the study time.
The results are similar to a previous study done on 2% prescription strength Nizoral where it was shown that use of 2% Nizoral yielded a 7% average increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.
So for any hair loss sufferer, this research clearly indicates that using 1% or 2% Nizoral 2-3 times per week, will have positive effects on hair growth as well as controlling dandruff. It is still unclear at this time whether it's the anti-fungal properties or the anti-androgenic properties of Ketokonazole (active ingredient in Nizoral) thats responsible for the hair thickening effects, however because of the decrease in sebum rates as well, it is the authors opinion that the results are due to the anti-androgenic properties of Ketokonazole.
Nizoral 1% Study
The effects of chronic use of 1% ketoconazole or a 1% zinc pyrithione shampoo on the general health of hair and scalp.
Hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, have used, in a double-blind fashion, a 1% ketoconazole shampoo or a 1% zinc pyrithione shampoo. The test shampoos were applied 2 to 3 times weekly for a total period of 6 months. Several parameters that affect the general health of hair and scalp were assessed at start, and after 1, 3 and 6 months. These parameters included the percent of hairs in anagen phase, the diameter of the hairs, sebum excretion rate at the hairline, and the number of hairs shed in the 24-hour period prior to each assessment. At the end of the study, the participants were asked to complete a questionnaire regarding the cosmetic acceptability of the test shampoos.
Forty-four ketoconazole users and forty-three zinc pyrithione users completed the 6 month study period. Analysis of the different parameters shows that the hair diameter gradually increases with chronic ketoconazole use (+8.46%) over a 6 month period, whereas the diameter shows a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate is reduced with ketoconazole (-6.54%) while it increases with zinc pyrithione (+8.2%) over the same period of time. The number of hair shed over a 24-hour period is reduced by 16.46% with ketoconazole and 6.02% with zinc pyrithione after 6 months. Finally, the percentage hairs in anagen phase increased by 6.4% and 8.4% respectively during the study time. Except for the percentage of hairs in anagen, which showed no difference between the two groups, all other parameters were significantly different in favor of the ketoconazole shampoo.
Both shampoos have been shown to be good anti-dandruff ingredients. Assessment of parameters than can affect the health of hair and scalp, suggests that both ingredients show distinct differences in the way they affect the scalp; indicating that ketoconazole increases hair diameter and reduces scalp oil, whereas zinc pyrithione seems to yield opposite effects. This suggests that, besides their effect on the lipophilic yeast Malassezia spp, ketoconazole and zinc pyrithione act though quite different mechanisms. An overall analysis of hair diameter changes as a function of changes in sebum excretion rate suggests that a reduction in scalp oiliness seems to result in an increased hair diameter. This suggests that, in people with oily hair, regular use of ketoconazole shampoo may result in overall hair fullness.
Ondertussen heb ik veel gelezen over haaruitval en de producten die er zijn om dit tegen te gaan op verschillende websites en ben ik begonnnen met de volgende behandeling: Nizoral 2% shampoo, Dr. Proctor's regrowth shampoo , 5% Xandrox (5% Minoxidil, 5% Azelaic Acid).
Sites waar je veel informatie kan vinden zijn www.regrowth.com, www.hairlosstalk.com, www.hairlosshelp.com . Als je al de informatie daar leest krijg je een goed beeld van hoe je haaruitval moet tegengaan en leer je ook dat de mate van je haaruitval genetisch voorbestemd is en niks te maken heeft met sex of bewegen of van die andere onnozele beweringen. Op www.hairlosshelp.com is er een "Ask the expert section" waar o.a. Dr. Proctor (www.drproctor.com) en Dr. Lee (www.minoxidil.com), toch wel twee autoriteiten op het gebied van haaruitval en de behandeling ervan vragen beantwoorden, als je daar een "search" doet in de reeds gestelde vragen kan je ook veel bijleren.
Om je haarverlies tegen te gaan heb je een groeistimulator nodig, de beste is Minoxidil, een andere groeistimulator is Nano, een soort natuurlijke Minoxidil ( nicotinic acid N-Oxide) en SODases (superoxide dismutases).
Er zitten SODases in de producten van Dr. Proctor en Folligen en Tricomin bevatten copper peptides.
"Oral minoxidil, a medication that originally was used to treat high blood pressure , has been found to increase hair growth. This lead to the development of topical (solution applied to the skin) minoxidil. Topical minoxidil (Rogaine) has been shown to stimulate hair growth."
"Superoxide dismutase. This is an enzyme produced by the body to neutralize the superoxide radical. Superoxide is a messenger of inflammation and is involved in the body's autoimmune response. It exists in a yin yang relationship with nitric oxide. Nitric oxide is a vasodilator that appears to be important for hair growth, while superoxide is a vasoconstrictor that may be part of the signaling mechanism that tells hair to stop growing. Superoxide can also interact with nitric oxide to form a highly destructive free radical called peroxynitrite, which causes protein and lipid oxidation. A few hair products contain copper peptides, which are SOD mimetics; i.e., mimic the effects of the body's SOD enzyme. SOD-containing products have been noted a number of times by researchers to stimulate hair growth and block hair loss in mice. Recent study data on Tricomin, a copper peptide SOD, indicates increased hair growth in MPB. Among other beneficial things, SODs appear to help spare growth-stimulating nitric oxide, reduce damaging inflammation, and help reverse fibrosis (follicular scarring). There are a few patents for SODs as hair growth stimulators and even one for an SOD inhibitor that blocks hair growth by increasing superoxide."
Om DHT tegen te gaan is het niet noodzakelijk van Finasteride te nemen. Azelaic Acid en Spironolactone die je op je scalp moet doen doen dit ook en hebben geen neveneffecten:
"Azelaic acid in Xandrox will inhibit virtually all synthesis of DHT in the scalp at the follicle level. It does this by inhibiting the synthesis of testosterone into DHT by both type 1 and type 2, 5-alpha reductase enzyme. On the other hand, Spironolactone blocks the follicular androgen receptor sites, inhibits the conversion of steroids to DHT, and converts testosterone into estrogen in the scalp. Azelaic acid cannot protect against circulating DHT. Topical spironolactone fulfills that need, but rather than reducing circulating DHT like finasteride does, it takes the place of it by blocking circulating DHT from the follicular receptor sites."
De beste shampoos die je kan gebruiken zijn Nizoral 2% shampoo en Nano shampoo van Dr. Proctor, je kan ook een "light" versie kopen van Nano shampoo, die Dr. Proctor's regrowth shampoo heet en goedkoper is bij www.anagen.net en www.lef.org
Je moet minstens 6 maanden wachten voor je resultaten kan verwachten en het beste is van een product 1 jaar te gebruiken om te zien of het echt werkt bij jou. Je moet ook realistische verwachtingen hebben, dun haar kan zogezegd "gemakkelijk" terug dikker worden maar plaatsen die al langer dan 5 jaar kaal zijn daar is het heel moeilijk om nieuw haar te laten groeien. Je moet de behandeling wel blijven volhouden want als je stopt ben je in 4 maanden al de resultaten ervan kwijt.
Ik denk dat dit de beste producten zijn:
- Nizoral 2% shampoo
- Nano shampoo, Proxiphen-N en Proxiphen zijn van Dr. Proctor (www.drproctor.com)
- 5% Xandrox of 12,5% Xandrox voor de recalcitrante plaatsen zoals de slapen en 5% Spironolactone van Dr. Lee(www.minoxidil.com)
- eventueel Folligen of Tricomin als bijkomende behandeling maar op zichzelf alleen zullen die niet veel uithalen
Hier is nog een studie van Nizoral shampoo:
Nizoral 1% Study Shows Benefits for Androgenetic Alopecia
March 04, 2001 - American Academy of Dermatology Meeting - Washington DC - Scientists working for McNeil, makers of Nizoral anti-dandruff shampoo, presented the findings of a study done on 1% Nizoral shampoo which has good news for hair loss sufferers. It has long been known that 2% prescription Nizoral has beneficial effects on Androgenic Alopecia (MPB). It however has been unclear whether the same benefits can be obtained by using the non-prescription 1% version.
In the study presented (see below), one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using, in a double-blind fashion, either a 1% Nizoral shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with Nizoral use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with Nizoral (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hair shed over a 24-hour period was reduced by 16.46% with Nizoral and 6.02% with zinc pyrithione after 6 months. Finally, the percentage hairs in anagen phase increased by 6.4% and 8.4% respectively during the study time.
The results are similar to a previous study done on 2% prescription strength Nizoral where it was shown that use of 2% Nizoral yielded a 7% average increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.
So for any hair loss sufferer, this research clearly indicates that using 1% or 2% Nizoral 2-3 times per week, will have positive effects on hair growth as well as controlling dandruff. It is still unclear at this time whether it's the anti-fungal properties or the anti-androgenic properties of Ketokonazole (active ingredient in Nizoral) thats responsible for the hair thickening effects, however because of the decrease in sebum rates as well, it is the authors opinion that the results are due to the anti-androgenic properties of Ketokonazole.
Nizoral 1% Study
The effects of chronic use of 1% ketoconazole or a 1% zinc pyrithione shampoo on the general health of hair and scalp.
Hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, have used, in a double-blind fashion, a 1% ketoconazole shampoo or a 1% zinc pyrithione shampoo. The test shampoos were applied 2 to 3 times weekly for a total period of 6 months. Several parameters that affect the general health of hair and scalp were assessed at start, and after 1, 3 and 6 months. These parameters included the percent of hairs in anagen phase, the diameter of the hairs, sebum excretion rate at the hairline, and the number of hairs shed in the 24-hour period prior to each assessment. At the end of the study, the participants were asked to complete a questionnaire regarding the cosmetic acceptability of the test shampoos.
Forty-four ketoconazole users and forty-three zinc pyrithione users completed the 6 month study period. Analysis of the different parameters shows that the hair diameter gradually increases with chronic ketoconazole use (+8.46%) over a 6 month period, whereas the diameter shows a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate is reduced with ketoconazole (-6.54%) while it increases with zinc pyrithione (+8.2%) over the same period of time. The number of hair shed over a 24-hour period is reduced by 16.46% with ketoconazole and 6.02% with zinc pyrithione after 6 months. Finally, the percentage hairs in anagen phase increased by 6.4% and 8.4% respectively during the study time. Except for the percentage of hairs in anagen, which showed no difference between the two groups, all other parameters were significantly different in favor of the ketoconazole shampoo.
Both shampoos have been shown to be good anti-dandruff ingredients. Assessment of parameters than can affect the health of hair and scalp, suggests that both ingredients show distinct differences in the way they affect the scalp; indicating that ketoconazole increases hair diameter and reduces scalp oil, whereas zinc pyrithione seems to yield opposite effects. This suggests that, besides their effect on the lipophilic yeast Malassezia spp, ketoconazole and zinc pyrithione act though quite different mechanisms. An overall analysis of hair diameter changes as a function of changes in sebum excretion rate suggests that a reduction in scalp oiliness seems to result in an increased hair diameter. This suggests that, in people with oily hair, regular use of ketoconazole shampoo may result in overall hair fullness.