Citaat:
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Oorspronkelijk geplaatst door Haarmannetje
Bovendien om toch een bepaalde link te leggen voor je. Men heeft het idee dat bij mensen met AGA ook microbacteriëen actief zijn in de hoofdhuid. Ik weet niet helemaal hoe dit zit, maar op de één of andere manier was het een opmerkelijk verschijnsel. Wellicht dat die microbacteriëen iets te maken hebben met AGA en dat daarom keto (omdat deze schimmels en bacteriëen doodt) zo succesvol blijkt. Ik zal eens wat informatie opzoeken over dit principe.
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Bedankt voor de prima aanvulling haarmannetje!
Wat betreft die link tussen AGA en micro-organismen: ik las daarover het volgende (KCZ = ketoconazol):
AGA is the androgenically driven hair loss in genetically predisposed adults. An inflammatory infiltrate rich in immunocompetent T lymphocytes is also present in the balding area [1, 2]. It has been postulated that both hormonal and immunoregulatory mechanisms act synergistically to potentiate follicular injury in AGA [1]. The reason why immunocompetent T cells abut on the external root sheath of transitional AGA hairs remains elusive. However, lipophilic microorganisms harbored in the infundibulum might represent the triggering factor [2]. KCZ was tested in AGA because it is active against Malassezia spp. and Stapkvlococcus spp. which are part of the scalp microflora. It also shows some direct anti-inflammatory effect [7-9]. The reduction in 'hair volume' is a notable feature of AGA. It depends on the hair number per unit area, hair diameter and duration of the anagen phase. PI and cross-section analysis of punch biopsies explored these aspects of the hair status. Left untreated, androgen-dependent alopecia progressively deteriorates [15]. This was found in the AGA subgroup using the nonmedicated shampoo alone. In contrast, both present studies concur to show an unequivocable effect of a 2% KCZ shampoo on hair variables affected by AGA. Hair density and size, and proportion of anagene follicles were all improved. Although the number of subjects was limited in the second study, results obtained with KCZ shampoo compare with minoxidil. It has been stated that medications capable of maintaining the existing hair population should be regarded as effective treatments for AGA [15]. The present data suggest that KCZ should enter this group of drugs. This indication is also supported by the fact that sebumetric analysis and morphometric evaluation of the volume of sebaceous glands indicate a trend in the decrease in sebum production by KCZ. Such a seboregulatory effect of KCZ has previously been suggested [16].
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