Acute Stress en Alopecia Areata
Alopecia areata and Affected Skin CRH Receptor Upregulation Induced by Acute Emotional Stress
By Robert Short
Acute emotional stress may trigger alopecia areata by activation of over-expressed type 2[b corticotrophin-releasing hormone receptors around the hair follicles. This in turn leads to intense local inflammation and loss of the hair. This is the conclusion of Dr Alexandra Katsarou-Katsari at the A Syggros Hospital for Dermatologic Diseases, University of Athens School of Medicine, Athens, Greece and colleagues in the USA. They investigated the expression of corticotrophin releasing hormone receptors on the affected skin of three patients (and one normal volunteer). The patients had developed alopecia areata following acute emotional stress. Said Dr Katsarou-Katsari, " Skin from the affected sites of all three patients studied showed intense expression only on the type 2b receptor around the hair follicles". In contrast the skin from the normal person showed only weak background expression of all three receptor types (type 1, type 2 a, and type 2b).
Dermatology 2001
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