[lanne]

http://www.hairlosstalk.com/newsletter/article233.htm

Wellicht betekent dit goed nieuws voor ons.

Wat denken jullie hiervan?

Revivogen in combination with Spironolactone

One newsgroup user raised an interesting and appropriate question: isn't Spironolactone more cost-effective than Revivogen? For every bottle of Revivogen that you buy, can't you buy a few bottles of ready-made Spiro. solution, or at least make your own? Yes, but remember that in these experiments there appeared to be a limit of effectiveness of Spiro. It seemed not to do any better above a certain dosage, and this level of effectiveness was lower than what was obtained with the GLA. If this is also true for human use for balding, then the use of Revivogen *might* be indicated for people who can't get the required level of antiandrogenicity through the usual means. However, to be fair to Spiro., there might be a reason for its relatively poor showing in these tests: all of these substances were given to the animals once a day. Spiro. is rather rapidly converted into its metabolite, canrenone, a *much* weaker antiandrogen. What if flank organs and sebaceous glands (and hair follicles) require a more continuous exposure to antiandrogens to get the desired effect? What if a fatty acid hangs around a lot longer, but Spiro. is metabolized and dissipated more quickly, requiring *twice* a day application? Would that mean that topical Spiro. at the proper dosage and used the proper way, could still be as effective as GLA? I frankly don't know the answer to that question, but I have to admit that it's a possibility. I don't have the data to say, either way.

But this leads me now to what I consider to be the *ideal* way to use Revivogen: use it along with topical Spironolactone! Disregarding the saw palmetto content of Revivogen for the moment, consider that GLA and the other fatty acids have no effect on the androgen receptors of hair follicles. Conversely, Spironolactone has no effect on 5AR; it does not block it at all. Think of the one-two punch you could have by combining *both* substances, and stopping or reducing activity on *both* sides of the 5AR enzyme! I feel that this combination is even more likely to serve successfully as a topical substitute for finasteride (Propecia), for those of us who are looking for such an alternative.