Citaat:
Oorspronkelijk geplaatst door Norwood_III
Merci, ik had nog maar weinig studies over lithium gelezen. Beter niet gebruiken dus.
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Nee jammergenoeg niet
. Maar zink (in versie2) zou ook GSK-3 verlagen:
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Lithium is not the only way to achieve inhibition of GSK-3ß; so is berilium (not recommended) and… good old zinc, which is a very safe ingredient to use and can be physiologically tolerated in relatively large quantities.
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Citaat:
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As I stated before, insulin-like effects of zinc should have hinted at the possibility that it may also act via inhibition of GSK-3ß, which is also linked to insulin resistance and type 2 diabetes. In an experiment, treating HEK-293 type cells with zinc resulted in increased activity of glycogen synthase and intracellular levels of ß-catenin, providing evidence for inhibition of GSK-3ß by zinc. In addition, zinc ions enhanced glucose uptake 3-fold in isolated mouse adipocytes, an increase similar to activation with saturated concentrations of insulin. The author then hypothesized that the in vivo insulin-mimetic actions of zinc are mediated via direct inhibition of endogenous GSK-3ß.
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Bron:
hier.