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19 augustus 2020, 14:17 | #106 |
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Geregistreerd: 25 november 2018
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Dat was een weekje, en tevens zeer lang geleden.
Inmiddels al lang geen last meer van. Deze post heb je letterlijk een keer eerder ge copy-paste, en daar heb ik je toen ook al antwoord op gegeven. Toont wel aan hoe sneu je bent. Nou toedeloe hè.
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Regime: - Orale DHT Blokker: Finasteride, 0.5mg 6x pw (07-2019), Dutasteride, 1x pw (09-2020) - Topische DHT Blokker & Groeistimulant: Essengen 6 Plus (06-2020) - Shampoo: Afwisselend Regenepure DR (01-2019), Nizoral shampoo (2018-12), en Biotin OGX Shampoo & Conditioner (10-2019) - Supplementen: Multivitamine complex en MSM poeder (05-2020) Laatst gewijzigd door PJKG; 20 augustus 2020 om 13:18 |
19 augustus 2020, 14:23 | #107 |
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Geregistreerd: 9 december 2013
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Wat een onzin opeens in dit topic. Waarschijnlijk ben je zelf ook bizar onzeker over je haar, aangezien je al deze tijd in onderzoek steekt en waarschijnlijk iedere dag wel iets leest over haaruitval. Net als ik overigens, laten we elkaar daar alsjeblieft niet op pakken, want zo leuk is het allemaal niet. Klinkt erg zwaar, maar ik beschouw haaruitval bijna als een ziekte.
Laten we het inhoudelijk houden. |
19 augustus 2020, 14:29 | #108 | |
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19 augustus 2020, 17:39 | #109 | |
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191 in 4 jaar 0,13 berichten per dag 588 in 16 jaar, 0,10 berichten per dag Over cognitieve capaciteit gesproken...
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Regime: Essengen 6 Plus 1ml s'avonds |
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19 augustus 2020, 18:33 | #110 | ||
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Citaat:
De ratio berichten per dag =/= de tijd dat je hier doorbrengt/leest. |
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4 september 2020, 20:44 | #111 |
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4 september 2020, 21:23 | #112 |
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9 september 2020, 14:05 | #113 |
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Dihydrotestosterone is the active androgen in the maintenance of nitric oxide
Studie: https://academic.oup.com/endo/articl...dFrom=fulltext The building blocks of erection: Nitric oxide...and more nitric oxide https://www.eurekalert.org/pub_relea...-tbb031502.php |
14 september 2020, 09:21 | #114 |
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Skip naar 1u36m, interessant fragment. |
20 september 2020, 13:55 | #115 |
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Nieuwe studie:
Alterations of gut microbiota composition in post-finasteride patients: a pilot study
Abstract Purpose Post-finasteride syndrome (PFS) has been reported in a subset of patients treated with finasteride (an inhibitor of the enzyme 5alpha-reductase) for androgenetic alopecia. These patients showed, despite the suspension of the treatment, a variety of persistent symptoms, like sexual dysfunction and cognitive and psychological disorders, including depression. A growing body of literature highlights the relevance of the gut microbiota-brain axis in human health and disease. For instance, alterations in gut microbiota composition have been reported in patients with major depressive disorder. Therefore, we have here analyzed the gut microbiota composition in PFS patients in comparison with a healthy cohort. Methods Fecal microbiota of 23 PFS patients was analyzed by 16S rRNA gene sequencing and compared with that reported in ten healthy male subjects. Results Sexual dysfunction, psychological and cognitive complaints, muscular problems, and physical alterations symptoms were reported in more than half of the PFS patients at the moment of sample collection. The quality sequence check revealed a low library depth for two fecal samples. Therefore, the gut microbiota analyses were conducted on 21 patients. The ?-diversity was significantly lower in PFS group, showing a reduction of richness and diversity of gut microbiota structure. Moreover, when visualizing ?-diversity, a clustering effect was found in the gut microbiota of a subset of PFS subjects, which was also characterized by a reduction in Faecalibacterium spp. and Ruminococcaceae UCG-005, while Alloprevotella and Odoribacter spp were increased compared to healthy control. Conclusion Gut microbiota population is altered in PFS patients, suggesting that it might represent a diagnostic marker and a possible therapeutic target for this syndrome. https://link.springer.com/article/10...18-020-01424-0 |
28 september 2020, 16:57 | #116 |
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Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm
Abstract 5?-dihydrotestosterone (5?-DHT) is the most potent natural androgen. 5?-DHT elicits a multitude of physiological actions, in a host of tissues, including prostate, seminal vesicles, hair follicles, skin, kidney, and lacrimal and meibomian glands. However, the physiological role of 5?-DHT in human physiology, remains questionable and, at best, poorly appreciated. Recent emerging literature supports a role for 5?-DHT in the physiological function of liver, pancreatic ?-cell function and survival, ocular function and prevention of dry eye disease and kidney physiological function. Thus, inhibition of 5?-reductases with finasteride or dutasteride to reduce 5?-DHT biosynthesis in the course of treatment of benign prostatic hyperplasia (BPH) or male pattern hair loss, known as androgenetic alopecia (AGA) my induces a novel form of tissue specific androgen deficiency and contributes to a host of pathophysiological conditions, that are yet to be fully recognized. Here, we advance the concept that blockade of 5?-reductases by finasteride or dutasteride in a mechanism-based, irreversible, inhabitation of 5?-DHT biosynthesis results in a novel state of androgen deficiency, independent of circulating testosterone levels. Finasteride and dutasteride are frequently prescribed for long-term treatment of lower urinary tract symptoms in men with BPH and in men with AGA. This treatment may result in development of non-alcoholic fatty liver diseases (NAFLD), insulin resistance (IR), type 2 diabetes (T2DM), dry eye disease, potential kidney dysfunction, among other metabolic dysfunctions. We suggest that long-term use of finasteride and dutasteride may be associated with health risks including NAFLD, IR, T2DM, dry eye disease and potential kidney disease. https://pubmed.ncbi.nlm.nih.gov/32202088/ |
18 oktober 2020, 15:51 | #117 |
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Gelden al deze heftige bijwerkingen ook voor saw palmetto?
Bijvoorbeeld Foligain Haargroei Capsules? Hebben dit soort capsules nut? Ik zie/lees nergens op dit forum dat iemand zoiets gebruikt als alternatief... voor fina Het zelfde vroeg ik me af over topisch fina.. is daar het effect al van bewezen in studies? |
18 oktober 2020, 17:20 | #118 |
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Deze studie uit 2019 heb ik nog niet gepost denk ik:
Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition Abstract Persistent alteration of plasma neuroactive steroid levels associated with major depression has been recently reported in men after the suspension of the treatment for androgenetic alopecia with finasteride, an inhibitor of the enzyme 5alpha-reductase. Observations in male rats confirmed persistent alterations in neuroactive steroid levels also in the brain. In the present study, we have ascertained possible effects on depressive-like behavior, neurogenesis, gliosis, neuroinflammation and gut microbiota in male rats after subchronic treatment for 20 days with finasteride and after one month of its withdrawal. At the end of treatment there was an increase in the number of pH3 immunoreactive cells in the subgranular zone of the dentate gyrus together with an increase in the mRNA levels of TNF-? in the hippocampus. By one month after the end of finasteride treatment, rats showed depressive-like behavior coupled with a decrease in the number of pH3 immunoreactive cells in the subgranular zone of the dentate gyrus, a decrease in granule cell density in the granule cell layer and an increase in the number of GFAP immunoreactive astrocytes in the dentate gyrus. Finally, alteration of gut microbiota (i.e., an increase in Bacteroidetes phylum and in Prevotellaceae family at the end of the treatment and a decrease in Ruminococcaceae family, Oscillospira and Lachnospira genus at the end of the withdrawal period) was detected. In conclusion, finasteride treatment in male rats has long term effects on depressive-like behavior, hippocampal neurogenesis and neuroinflammation and gut microbiota composition. https://www.sciencedirect.com/scienc...06453018305067 |
18 oktober 2020, 17:25 | #119 | |
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Maar topische duta is wel interessant, verschillende mensen die dit wel kunnen verdragen maar niet orale of topische fina. Kan te maken hebben met dit: https://fuehairdoctor.co.uk/topical-...e-dr-lupanzula |
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30 oktober 2020, 14:11 | #120 |
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Ter verduidelijking, dit zijn al de processen die verstoord worden door finasteride, het gaat dus veel verder dan enkel een effect op DHT zoals vele denken:
https://en.wikipedia.org/wiki/5%CE%B...pmid21361868-9 The following reactions are known to be catalyzed by 5?-reductase:[9]
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bijwerkingen finasteride, bijwerkingen minoxidil |
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