Saw palmetto studie op AGA

[Jaapie]

After years of speculation, there is finally a study assessing the effects of saw palmetto on androgenetic hair loss. The results indicate that it is well worth using, and may in fact provide a side effect free, alternative to Propecia. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia.

Journal of Alternative and complimentary Medicine.
Apr. 2002;8(2): 143-52 Clinical Research and Development Network, Aurora, CO, USA.
BACKGROUND: Androgenetic alopecia (AGA) is characterized by the structural miniaturization of androgen-sensitive hair follicles in susceptible individuals and is anatomically defined within a given pattern of the scalp. Biochemically, one contributing factor of this disorder is the conversion of testosterone (T) to dihydrotestosterone (DHT) via the enzyme 5-alpha reductase (5AR). This metabolism is also key to the onset and progression of benign prostatic hyperplasia (BPH). Furthermore, AGA has also been shown to be responsive to drugs and agents used to treat BPH. Of note, certain botanical compounds have previously demonstrated efficacy against BPH. Here, we report the first example of a placebo-controlled, double-blind study undertaken in order to examine the benefit of these botanical substances in the treatment of AGA.

OBJECTIVES: The goal of this study was to test botanically derived 5AR inhibitors, specifically the liposterolic extract of Serenoa repens (LSESr) and beta-sitosterol, in the treatment of AGA. Subjects: Included in this study were males between the ages of 23 and 64 years of age, in good health, with mild to moderate AGA.
RESULTS: The results of this pilot study showed a highly positive response to treatment. The blinded investigative staff assessment report showed that 60% of (6/10) study subjects dosed with the active study formulation were rated as improved at the final visit. CONCLUSIONS: This study establishes the effectiveness of naturally occurring 5AR inhibitors against AGA for the first time, and justifies the expansion to larger trials.

[ugh]

Er zijn redelijk wat mensen tegen SP. (Ik ben zelf neutraal op dit moment.)

Hier wat tegens:
http://www.hairsite4.com/dc/dcboard....8039&mode=full
http://www.hairlosstalk.com/newslett...rticle&sid=230

Saw Palmetto: Zero Clinical Data for Hair Loss

There hasn't been a single reputable study done showing that Saw Palmetto has any effect on treating hair loss. One study can be found in PubMed, but it was run by the makers of a saw palmetto product, and was publicly labeled as "Bunk" on 20/20 in January 2003 on nationwide television because it only included 10 participants and lasted only 6 months. Insufficient test group, insufficient test period, and run by someone standing to gain financially from it.

[Gerben]

Zo lang ik op dit forum zit, verwijs ik al naar dit artikel. Het is een redelijk overtuigend verhaal, maar helaas tot heden nog het enige dat de relatie tussen SP en haaruitval heeft onderzocht. Hopelijk komen er meer!