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Oud 30 maart 2004, 17:34   #1
pindakaas
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Soja

Soy consumption could help prevent male pattern baldness...

Public release date: 29-Mar-2004

Contact: Jim Feuer
jim.feuer@cchmc.org
513-636-4656
Children's Hospital Medical Center of Cincinnati

Soy consumption could help prevent prostate cancer and male pattern baldness

CINCINNATI -- A team of scientists has discovered that a little-known molecule created in the intestine when soy is digested is a natural and powerful blocker of a potent male hormone involved in prostate cancer and male pattern baldness. In fact, the molecule, equol, completely stops in its tracks the male hormone dihydrotestosterone (DHT), which normally stimulates prostate growth and causes male pattern baldness.
"This molecule is remarkable," says Kenneth Setchell, PhD, director of Clinical Mass Spectrometry at Cincinnati Children's Hospital Medical Center, who first identified equol in humans 20 years ago. "These findings are of immense clinical importance because blocking the action of the potent androgen (male hormone) DHT has been one of the holy grails of the pharmaceutical industry as a strategy for treating prostate cancer and other related diseases. This natural metabolite made from soy isoflavones, which are found in high amounts in soybeans, does this very effectively."

The study, which tested the response to equol in rats, was conducted at Colorado State University, Brigham Young University, and Cincinnati Children's and appears in the April edition of Biology of Reproduction.

In recent years, the pharmaceutical industry has developed drugs that inhibit a certain enzyme that converts testosterone to DHT. Unfortunately, these drugs have side effects. Equol, on the other hand, doesn't prevent DHT from being made but prevents it from functioning. It puts "handcuffs" on DHT, preventing it from binding to the androgen receptor and thereby preventing the prostate from growing. This may be particularly important for men who have been diagnosed with either an enlarged prostate (benign prostatic hyperplasia, or BPH) or cancer of the prostate.

"Directly binding and inactivating DHT without influencing testosterone gives equol the ability to reduce many of the harmful effects of androgens without affecting the beneficial ones," said Robert J. Handa, PhD, senior author of the study and professor in the department of biomedical sciences at Colorado State's College of Veterinary Medicine.

"The novelty of equol is that it both inhibits androgen hormone and influences estrogen hormone action," adds Edwin Lephart, PhD, professor of physiology and developmental biology and director of the Neuroscience Center at Brigham Young University. "We do not know of any other molecule that possesses these important biochemical properties."

Two experiments demonstrated that injections of equol into male rats reduced the size of the prostate. In one study, the testes of male rats were removed, thereby eliminating all DHT production. When investigators injected DHT into rats, their prostates grew. When they gave rats equol, nothing happened at all. When they injected rats with both equol and DHT, the equol prevented the DHT from functioning as it normally would – as a stimulator of prostate growth.

In other words, equol did not change hormone levels but completely blocked the effects of DHT in rats. This could explain why men in Japan, who eat more soy than American men but suffer equally from BPH as they age, rarely go on to have prostate cancer, according to Dr. Setchell. Several human studies have demonstrated the advantages of eating soy in reducing the risk of prostate cancer.

So far, research has established the relevance of DHT in the growth of male reproductive organs and, given the importance of DHT in the skin, it is possible that equol may offer a means of controlling hair loss and promoting healthy skin. The researchers have initiated further studies of equol to assess its potential as a treatment for a variety of other androgen-mediated conditions. The team has filed patent applications on equol and hopes to commercialize the technology.

The lead author of the study was Trent Lund, assistant professor in the department of biomedical sciences at Colorado State.

Bron: Soy Product
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M
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finasteride

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cetirizine



--'blablabla'--

Laatst gewijzigd door Tiuri; 24 maart 2005 om 09:25
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Oud 30 maart 2004, 18:40   #2
Jaapie
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Clare M. Hasler, Ph.D. (c-hasler@uiuc.edu)
Thu, 16 Jul 1998 10:40:06 -0500 (CDT)

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--------------------------------------------------------------------------------
No, there is no research to support the rumor that soy can help prevent
baldness.

Regarding the soy products sold in nutrition stores, it depends on the type
of supplement.


All substances are deletenous if taken at too high of a dose--the primary
principle of toxiology. Very high amounts of the phytoestrogens in legumes
have been linked with infertility in animals and have been shown to alter
menstrual cycle lengths in women.


Clare M. Hasler, Ph.D.


At 09:08 AM 7/13/98 -0500, you wrote:
>Rumor has it that soy can be helpful in preventing male
>pattern baldness. Is there any research to support
>this?
>
>And if I decide on a soy supplement, what do you think of
>the soy products sold in nutrition stores? Are there
>any bad effects of taking too much?
>---------------------------------------------------------------------------
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Oud 30 maart 2004, 18:41   #3
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Soy Study

French researchers compared the effects of a soyextract vs. genistein and daidzein (isoflavones devoid of their carbohydrate conjugates) and daidzin and puerarin (carbohydrate conjugated isoflavones; puerarin is present in abundance within kudzu [Pueraria lobata]) on different hormone elements and isolated human hair follicles.
'Activation' of the gene coding for an enzyme implicated in androgenetic hair loss (5alpha-reductase; the target of the drug finasteride, for androgenetic alopecia) was inhibited by both genistein and puerarin. Genetic activation of an enzyme involved in the conversion of testosterone into estrogens (aromatase) was increased by genistein and, to a lesser extent, daidzein.

The soy extract stimulated one of the estrogen receptors (b receptor) greater than genistein and daidzein, although the latter two were stimulatory themselves. Receptors for testosterone-like molecules (androgens) were decreased by genistein, and half as much by daidzein.

But what does all this molecular hormone 'geek speak' mean? The researchers found a 30 per cent increase in hair growth with the soy extract. Woven together, these data suggest that an isoflavone mixture, perhaps ideally from soy (but yet to be confirmed) could arrest hair loss in conditions where androgens are playing an operative role.

Soy Patent for Hair Loss

An American Herb company was recently issued a patent for the use of soy extract for the treatment and prevention of hair loss. Following are excerpts from the patent itself.

"The present invention is based on the principle that plants and plant extracts containing isoflavones can inhibit hair loss. Plants or plant extracts containing isoflavones can be administered either orally or topically to prevent hair loss.

The present invention provides the additional benefit that the administration of isoflavone-containing plants or plant extracts can provide other health benefits in addition to preventing hair loss. Another advantage of the invention is that the isoflavone-containing plants and plant extracts can be combined with other pharmaceutical treatments for preventing hair loss without adversely affecting the beneficial and positive effects of such treatments.""It is a further object of the invention to provide a method of preventing hair loss which may be used orally."

"The present invention is based on the principle that plants or plant extracts containing isoflavones may be administered orally or topically to prevent hair loss."

"The isoflavones of the present invention include those which exhibit estrogenic activity and which bind to testosterone receptors. Such isoflavones prevent the "hair loss" effect of testosterone by inhibiting the binding of testosterone to the hair and scalp receptor, thereby resulting in maintenance of scalp hair integrity."

"The present invention includes compositions containing isoflavones in general, and particularly soybean isoflavonoids, may be used to prevent hair loss in mammals, including both in men and women, by the aforementioned mechanism of action.

Such isoflavones may include, but are not limited to, genistein (II) and variants thereof. Genistein is also termed 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one or 4',5,7-trihydroxy-isoflavone Sources of the preferred isoflavones include soy and other members of the Leguminosae family and the Rosaceae, Podocarpaceae, Iridaceae, Moraceae, Amarantaceae and Compositae families, as will be appreciated by those in the art."

"Orally-administrable dosage forms of the invention may include, but are not limited to, capsules, tablets, powders and liquids (hereinafter referred to as "oral dosage forms"). Other equivalent oral dosage forms are within the scope of the invention, as will be readily appreciated by those of skill in the art. As an oral dosage form, the composition may be administered alone or in combination with food."

"In a still more preferred embodiment of the invention, an oral dosage form contains from about 400 to about 500 mg total weight plant or plant extract. In the most preferred embodiment, the oral dosage will contain about 450 mg of isoflavone-containing plant or plant extract.

The total amount of plant, plant extract, carriers, excipients, diluents, lubricants and other so-called "pharmaceutical aids" included in an oral dosage form may be varied according to the preferred size of the oral dosage form. For capsules, the total weight may range from about 275 mg to about 500 mg, although greater or lesser capsule weights are within the scope of the invention."

"In its oral form, the composition may be taken alone or in combination with food or liquids. In the preferred embodiment of the invention, the composition is preferably taken with a meal or with liquid. Generally from 1 to 2 oral doses may be taken in from 1 to 4 or more times a day."

Japanese Diet

The rural Japanese, who traditionally have low rates of breast and prostate cancer, and almost no incidence of male pattern balding typically consume 20-80 mg. of genistein a day, a phytochemical almost entirely derived from soy beans.

In the US, where pattern loss in epidemic, the daily dietary intake is only 1 to 3 mg. Previously, doctor's thought that the disproportionate amount of androgen mediated disorders, i.e. prostate cancer, acne, and pattern loss was because of the high fat content of the western diet. New studies, however, fail to show a significant link between dietary fat and these types of disorders.

Many researchers have now concluded that the heightened incidence of these disorders results from a diet that is deficient in soy. For the treatment or prevention of pattern hair loss it would be reasonable to consume 300-500 mg. of soy extract (not just protein) a day, preferably in divided doses.
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Oud 3 april 2004, 19:34   #4
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Wat is Soy?
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Intern:
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Xandrox 15 ( om de dag )

Status; Stabilisatie

Laatst gewijzigd door Tiuri; 24 maart 2005 om 09:55
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Oud 3 april 2004, 19:49   #5
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.... Soja
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Oud 5 mei 2004, 15:19   #6
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soja

in de nieuwe men's health staat ook dat soja zou helpen...
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Oud 5 mei 2004, 16:14   #7
Haarmannetje
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Kun je hier misschien iets duidelijker over zijn? Op welke manier is soja goed? Wat is de achterliggende gedachte ervan?
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Oud 5 mei 2004, 16:20   #8
Jack
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and i quote:"de Isoflavonen uit soja blijken effect te hebben op de haarfollikelsze activeren een enzym dat de mannelijke vorm van kaalheid tegen gaatomdat meer testosteron wordt omgezet in oestrogeen" en verder " Onderzoekers vonden een toename van de hoofdhaargroei van 30 procent bij proefpersonen die een soja-extract tot zich namen."
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Oud 5 mei 2004, 16:24   #9
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soja?? Waar moet dat inzitten dan?
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Oud 5 mei 2004, 16:25   #10
Jack
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he gaat hier trouwens om de "vrouw" versie van men's health. staat trouwens ook een stukje over hoe vrouwen ons kunnen "helpen" bij als er dingen met ons gebeuren en bij kaalworden staat geen soja eten, maar hem wijzen om het feit van het bestaan van finasteride.
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suffers from itchy and scratchy discease....

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Oud 5 mei 2004, 16:50   #11
Haarmannetje
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Er staat inderdaad in dat het een plantaardige oestrogenen bevat. Dat lijkt mij dus minder geschikt voor de man, toch? Nu ik er over nadenk. Er zijn genoeg mannelijke vegetariërs, die bijvoorbeeld sojabonen eten i.p.v. vlees. Maar als daar dan oestrogenen in zitten, dan is dat toch helemaal niet goed voor die mannen? Wie weet hier iets meer van?
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Oud 5 mei 2004, 16:52   #12
Haarmannetje
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Citaat:
Oorspronkelijk geplaatst door Mcsnip
soja?? Waar moet dat inzitten dan?
Soja is volgens mij al een eigen product, dat vooral in Azie voorkomt. Er wordt van alles van gemaakt: sojabonen, sojamelk enzovoort.
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Oud 5 mei 2004, 16:54   #13
Jack
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sorry maar je maakt geen sojabonen, http://www.gezondheid.be/index.cfm?f...rt&art_id=1769. hier even wat aanvullende info.
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suffers from itchy and scratchy discease....

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Oud 5 mei 2004, 17:00   #14
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kijk hier maar even.
http://www.haarweb.nl/forum/showthre...highlight=soja
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Oud 16 mei 2004, 20:48   #15
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Denk niet dat soja helpt. Bij mij niet althans. Ik drink al anderhalf jaar een halve liter sojamelk per dag. En mijn haren vallen nog steeds met bosjes uit...
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