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Oorspronkelijk geplaatst door laurensj
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Ik heb zojuist ook al vermeld hoe je bij die info kon komen.
Het mij niet lukte om die link te vermelden.
I repeat: via thread: na hoop komt wanhoop
zie reactie van Cloud.
Een van de linkjes waar je onder de reactie van de arts naar kan doorklikken is deze:
Re: A Word of Caution on Avodart(Score: 0)
by on Jun 07, 2003 - 06:00 PM
Here's the neurological info (central nervous system toxicity) on dut from the
Glaxo "Prescribing information":
CNS Toxicity: At 425 and 315 fold the expected clinical drug some rats and dogs
exhibited signs of non-specific, reversible, centrally-mediated toxicity without
associated histopathological changes.
Note that only 'some' and not all rats and dogs had signs of neural toxicity. I
think if you ate 300 times the table salt you normally now do, you would
probably have "non-specific, reversible, centrally-mediated [CNS] toxicity".
Actually, you would probably wouldn't survive very long.
Also, does dutasteride cross the blood-brain barrier readily and enough quantity
when taken at 0.5 mg/day to reduce 5AR-1 activity in the brain? The blood-brain
barrier is a formidable deterrent against relatively small concentrations of
substances entering the brain. Testosterone, which is chemically similar to
dutasteride, does cross the blood-brain barrier, but dutasteride has many
modifications in it's chemical structure (it's quite electronegative) that may
prohibit it's crossing that barrier except at high does (for example, 300 times
the normal dose).
5AR-1 does play a role in the CNS - it's thought to prevent neurological
toxicity by catabolism of neurotoxic steriods. It also functions to convert
progesterone to dihydroprogesterone (DHP) in the brain - a beneficial
neurosteroid. 3-alpha-HSD (another enzyme in the brain) converts DHP to
allopregnanolone. Allopregnanolone is a neurosteroid which exhibits anxiolytic
(anti-anxiety) and anticonvulsant activities through potentiation of the GABA(A)
receptor. So if you start feeling more anxiety or have seizures, stop taking
dutasteride and tell your doctor (and Glaxo).
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