Nieuwe studie;
The Potential Involvement of Cholinergic System in Finasteride Induced Cognitive Dysfunction
Highlights
•Repeated finasteride (100?mg/Kg, s.c.) administration impairs memory
•Finasteride (100?mg/Kg, s.c.) decreases sociability and social preference
•Reduced AChE activity in discrete brain regions after finasteride administration
Conclusion
Our study provides evidence that repeated administration of finasteride decreases social interaction and results in cognitive deficits, potentially through a cholinergic mechanism. Further studies are required to understand the exact link between the cognitive effects and the cholinergic system. A deeper probe of the current findings holds promise for the development of novel neurosteroid-based therapeutics to treat affective and cognitive disorders.
https://www.sciencedirect.com/scienc...04893?via=ihub