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Oud 26 december 2018, 16:53   #29
Pionier
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https://www.hairlosstalk.com/interac.../#post-1747235


In this study, the effects of chitosan and surface-deacetylated chitin nanofibrils (SDACNFs) on hair growth were evaluated. In human follicle dermal papilla cells in vitro, chitosan and SDACNFs were shown to increase cell proliferation on day 3 after the initiation of treatment, together with an increase in the production of fibroblast growth factor-7 (FGF-7) by these cells on day 3. Furthermore, in an in vivo study in mice, chitosan and SDACNF application promoted hair growth. The number of anagen follicles significantly increased compared with that in the control group, whereas the number of telogen follicles significantly decreased in the chitosan and SDACNF groups. In the chitosan and SDACNFs groups, moreover, the expression levels of FGF-7 and Sonic hedgehog were significantly upregulated in hair follicles. Overall, our results demonstrated that chitosan and SDACNFs promoted hair growth and therefore may have applications as novel therapeutic agents for the treatment of hair loss in patients.
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Chitosan increased:

? Sonic hedgehog - a key regulator of hair growth that declines in the catagen phase. Important for shifting hairs into anagen phase, combined with wounding it has the potential for hair follicle neogenesis.
https://www.hairlosscure2020.com/the...ealized-dream/

? FGF-7 - is important for the entry of the follicle into anagen phase

? VEGF - maintains proper vascularization of the hair follicle and promotes angiogenesis, ensuring proper blood supply and maximum hair diameter during the anagen phase

Chitosan can be bought online in powder form and is soluble at 1% in 1% acetic, adipic, formic, lactic, malic, propionic, or succinic acid.



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