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Oud 1 maart 2021, 17:27   #151
Pionier
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Nieuwe website met veel info over PFS:


https://www.pfsnetwork.org/







En finasteride heeft weer veel negatieve aandacht gekregen in de pers enkele weken terug:


https://www.reuters.com/article/us-m...-idUKKBN2A32XU


(Reuters) - Newly unsealed court documents and other records show that Merck & Co and U.S. regulators knew about reports of suicidal behavior in men taking the company’s anti-baldness treatment Propecia when they decided not to warn consumers of those potential risks in a 2011 update of the popular drug’s label.


https://www.dailymail.co.uk/health/a...ords-show.html

Merck KNEW its anti-baldness drug Propecia was linked to depression and reports of suicide but decided not to update the medication's warning label, documents show​


https://www.businessinsider.com/excl...true&r=US&IR=T

Merck knew about suicidal behavior in men taking anti-baldness drug Propecia, yet failed to warn consumers of these risks​

Dit nieuws kwam ook nog op een pak andere bekende zenders, etc.

Laatst gewijzigd door Pionier; 1 maart 2021 om 17:32
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Oud 1 maart 2021, 20:23   #152
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Oorspronkelijk geplaatst door Pionier Bekijk bericht
Snap ik maar besef dat er alternatieven bestaan. Ze zijn misschien minder effectief als fina, maar je gezondheid is belangrijker.



Lees de thread en hier wat verder op het forum voor alternatieven. Maar uiteindelijk beslis je zelf wat je neemt.
Welke alternatieven zou jij mij aanraden en is het innemen van fina of duta nogsteeds schadelijk wanneer je echt kleine hoeveelheden inneemt?
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Oud 2 maart 2021, 14:42   #153
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Oorspronkelijk geplaatst door FVDS Bekijk bericht
Welke alternatieven zou jij mij aanraden en is het innemen van fina of duta nogsteeds schadelijk wanneer je echt kleine hoeveelheden inneemt?
Heb je een pm gestuurd.
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Oud 2 maart 2021, 18:11   #154
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Heb je een pm gestuurd.
Thanks man 👊
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Oud 16 augustus 2021, 15:29   #155
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Al tijdje geleden maar hier nog een paar updates:


Het o zo veilige finasteride heeft een nieuwe officiële waarschuwing gekregen van de FDA voor hematospermia.


https://twitter.com/i/web/status/1421157529875357701


Nieuwe reportage van duitse omroep over finasteride:





Ook zeer interessant om te weten is dat FDA gewoon toegeeft dat ze niet weten wat de lange termijn effecten zijn van finasteride:


https://twitter.com/FinasterideInfo/...09906664464385


Ondanks werd het toch goedgekeurd, maar ja we weten al langer hoe corrupt FDA is: https://ethics.harvard.edu/blog/risk...not-be-trusted


En belangrijkste van al, een nieuwe studie:


https://pubmed.ncbi.nlm.nih.gov/34247957/


Differential Gene Expression in Post-Finasteride Syndrome Patients



Clinical implications: In this study we present evidence of gene expression correlating with observed biologic differences in patients with post-finasteride syndrome; providers who prescribe 5ARIs should be aware and advise their patients accordingly.


Strengths & limitations: Strengths of this study include the evaluation of multiple proposed etiologies for post-finasteride syndrome. The study is also strengthened by the fact that not all data matched the initial hypotheses, qualifying the argument for the existence of PFS. Limitations include potential selection bias arising from more severe phenotypes seeking care; lack of gene expression data prior to 5ARI exposure; lack of non-penile tissue samples supposedly involved; and a lack of mechanistic data to imply causality.


Conclusion: This study is the first to consider and demonstrate gene expression differences in patients with PFS as a potential etiology of sexual dysfunction.
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Oud 6 december 2021, 14:58   #156
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https://academic.oup.com/edrv/article/38/3/170/3861397


Is Dihydrotestosterone a Classic Hormone?








DHT is een uniek hormoon, testosteron is geen substituut voor DHT.






Nieuwe studies:


https://onlinelibrary.wiley.com/doi/...sec-0008-title




Dihydrotestosterone in Amyotrophic lateral sclerosis—The missing link?​


Conclusions:​


DHT is probably integral to survival of motor neurons. In patients predisposed to develop ALS, there is possibly a sort of “testosterone resistance” at level of blood–brain barrier [BBB] existing right from birth and is likely the result of dysfunctional transport protein involved in testosterone transfer across the BBB. In these patients, lesser amount of testosterone is able to breach the BBB and enter the central neural axis. Lesser amount of testosterone is available to 5 α reductase in the anterior pituitary to be converted to DHT and lesser amount of DHT is generated. There is inadequate negative feedback suppression of LH at the level of anterior pituitary by DHT. As a result of higher LH levels, testosterone levels rise in the peripheral testosterone fraction [the fraction outside the BBB] and this explains the various physical attributes of ALS patients like lower Ratio of the index and ring finger lengths (2D:4D ratio), increased incidence of early onset alopecia etc. This deficiency of DHT leads to motor neuron death causing ALS.

-----


https://content.iospress.com/article...cine/jrs210023

A large international team of researchers proposes for the first time diagnostic criteria for permanent sexual dysfunction caused by the SSRI/SNRI antidepressants, finasteride and isotretinoin.​


Abstract: BACKGROUND:A set of enduring conditions have been reported in the literature involving persistent sexual dysfunction after discontinuation of serotonin reuptake inhibiting antidepressants, 5 alpha-reductase inhibitors and isotretinoin. OBJECTIVE:To develop diagnostic criteria for post-SSRI sexual dysfunction (PSSD), persistent genital arousal disorder (PGAD) following serotonin reuptake inhibitors, post-finasteride syndrome (PFS) and post-retinoid sexual dysfunction (PRSD). METHODS:The original draft was designed using data from two published case series (Hogan et al., 2014 and Healy et al., 2018), which represent the largest public collections of data on these enduring conditions. It was further developed with the involvement of a multidisciplinary panel of experts. RESULTS:A set of criteria were agreed upon for each of the above conditions. Features of PSSD, PFS and PRSD commonly include decreased genital and orgasmic sensation, decreased sexual desire and erectile dysfunction. Ancillary non-sexual symptoms vary depending on the specific condition but can include emotional blunting and cognitive impairment. PGAD presents with an almost mirror image of unwanted sensations of genital arousal or irritability in the absence of sexual desire. A new term, post-SSRI asexuality, is introduced to describe a dampening of sexual interest and pleasure resulting from a pre-natal or pre-teen exposure to a serotonin reuptake inhibitor.

CONCLUSIONS:These criteria will help in both clinical and research settings. As with all criteria, they will likely need modification in the light of developments.

Following institutions have worked on this diagnostic criteria study:

Affiliations: [a] Department of Family Medicine, McMaster University, Hamilton, ON, Canada | University Counseling Service, University of Iowa, Iowa City, IA, USA | [c] Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands | [d] FACT, Mondriaan Mental Health, Maastricht/Heerlen, The Netherlands | [e] Unit for Quality of Care and Rights Promotion in Mental Health, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy | [f] IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy | [g] Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA | [h] Department of Health Sciences, University of Florence, Florence, Italy | Clinical Pharmacopsychology Laboratory, University of Florence, Florence, Italy | [j] Department of Anatomy, Howard University College of Medicine, Washington, DC, USA | [k] Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy | [l] Alvarado Hospital, San Diego, CA, USA | [m] San Diego Sexual Medicine, San Diego, CA, USA | [n] Department of Psychiatry and Psychotherapy, Ulm University, Ulm, Germany | [o] Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA | [p] Beth Israel Deaconess Medical Center, Boston, MA, USA | [q] Harvard Medical School, Boston, MA, USA | [r] Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy | Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Centre, Maastricht, The Netherlands | [t] Department of Hospital Pharmacy, VieCuri Medical Center, Venlo, The Netherlands | Department of Urology, Baylor School of Medicine, Houston, TX, USA | [v] Institute for Mind and Brain, Kerala, India | [w] North Wales Department of Psychological Medicine, Bangor, Wales, UK | [x] Department of Psychiatry, Centre of Postgraduate Medical Education, Warsaw, Poland | [y] School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands | [z] Department of Psychology and Psychotherapy, Witten/Herdecke University, Germany | [aa] Psychiatry Service, Hospital Universitario San Agustín, Avilés, Asturias, Spain | [ab] Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK | [ac] Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK | [ad] Carver College of Medicine, University of Iowa Health Care, Iowa City, IA, USA | [ae] Department of Psychology, Queen’s University, Kingston, ON, Canada | [af] Faculty of Social and Behavioural Sciences, Utrecht University, Utrecht, The Netherlands | [ag] Flare-Health, Amstelveen, The Netherlands | [ah] Department of Urology, Georgetown University School of Medicine, Washington, DC, USA | [ai] Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands | [aj] Private Practice, Pasadena, CA, USA | [ak] Psychiatric Clinic, Slovak Medical University and University Hospital, Bratislava, Slovakia

Laatst gewijzigd door Pionier; 6 december 2021 om 15:02
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Oud 7 december 2021, 10:29   #157
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New Drugs Found to Cause Side Effects Years After Approval​

Almost one-third of new drugs approved by the FDA ended up years later with warnings about unexpected, sometimes life-threatening side effects.


https://www.nbcnews.com/health/healt...proval-n757526


------------


DHT - HOW IT AFFECTS THE BRAIN - AND NERVOUS SYSTEM


But anyway, we got carried away. Let's go on to discuss DHT's effects in the Brain.
DHT has pronounced effects on neurochemistry (it affects neurotransmitters in the brain). DHT has been shown to increase circulating epinephrine levels (adrenaline), this can cause anxiety in predisposed individuals, however, most of the time, this is not the case, since DHT also increases GABA activity in the brain, which is relaxing (10) (11) (12). So in other words, DHT should promote A focused, calm burst of energy, which is what many users of DHT-based steroids, report as the "alpha-male" feeling (13) (14). Dihydrotestosterone increase central and nervous system energy production by increasing not just adrenaline, but cyclic AMP (15). This molecule increase thermogenesis (fat-burning and heat production)(16). Cyclic AMP facilitates the conversion of TSH thyroid hormone, to T4, a more potent thyroid hormone, thus, indirectly, DHT increases thyroid function (by increasing cyclic AMP) (17).

So seeing all this, DHT definitely acts as a nervous system stimulant, and a metabolic "probe", it also increases GABA. Second to this though, it could indirectly decrease serotonin or serotonin receptors; since DHT antagonizes estrogen activity, and estrogen helps maintain the expression of serotonin receptors in the brain(18) (19). This is also consistent with DHT being shown to stop estrogen induced prolactin release(20).
This is part of the reason behind using DHT Gel to treat gynecomasita. Clearly DHT has anti-depressant effects, since Finasteride causes depression (21) and also based on the above mentioned activity of DHT in the brain. It gives energy, it gives focus, it gives aggression.

DHT also improves spatial working memory(22), according to some studies, by altering NMDA-receptors(23) (namely increasing), and by improving Calcium-induced acetylcholine release & function in the hippocampus(24)(25); a very important area of the brain involved in memory formation and spatial (directional) memory.

DHT also decreases glutamate levels and excitory outputs through other mechanisms (26) (27) (28).


Finally, Dihydrotestosterone, or it's metabolite 3-alpha-Diol; downregulate alpha-adrenergic receptor distribution, leading to more inhibitory adrenergic (adrenaline influence)(29) (30) (31). For those who don't know, adrenaline can activate an 'alpha receptor' - which stimulates the nervous system, vasoconstricting blood vessels and arteries, raising blood pressure, or it can activate a beta-adrenergic receptor, generally vasodilating artieries, but yet, increasing heart contractile force. This all might just be another result or a reflection of what is mentioned above, that DHT increases epinephrine, GABA, and cyclic AMP. However, in a separate study, Testosterone (without specificity), had upregulated alpha-1-receptors to protect the heart against ischemia(32). Is this an effect of Testosterone or it's metabolites though. Likely, it doesn't matter, it was probably case coincidental, but may indicate that if blood pressure falls too low, Testosterone can increase it to maintain homeostasis.

In yet another study however, DHT has been shown to increase alpha-1-adrenergic expression, whereas Estrogen decreased the expression/density(33).
This again reflects the need for DHT and Estrogen to be kept in balance, as both promote vasodilation through different pathways, however, since Alpha-1-receptors are incredibly potent Vasoconstrictors, DHT + an OVERALL deficiency in nitric oxide may actually promote high blood pressure, especially in coordination with estrogen deficiency. Interestingly, Alpha-1-receptor activation may increase serotonin activity at the 5-HT1A receptor(34)(35), this is an auto-receptor that ironically seems to possess anxiolytic (serotonin-typical) effects. 5-HT1A activation has shown to help social anxiety disorder, but worsen anticipation anxieties(36)(37).
In another study, DHT/Androgens also facilitated serotonin 5-HT1A/1B agonist-decreases in aggression, which is controversial, although it appears that estrogen allows for intermale aggression by downregulating serotonin 5-HT1A/1B activity(38)(39). Thus DHT's only pro-aggressive propertly lies in it's adrenaline promoting effect, and not with serotonin.



OTHER CENTRAL AND MOLECULAR CHANGES INDUCED BY DIHYDROTESTOSTERONE





  1. Dihydrotestosterone appears to strongly increase MAPK; Mitogen-Activated-Protein-Kinase - this leads to a plethora of central and molecular changes as well as genomic/expressional changes(40)(41).
  2. This action further reinforces and validates DHT's suppressive effects on serotonin systems (42) since activating MAPK leads to increased serotonin transporter (SERT) activity - an effect directly opposite of SSRI's (43) (44) (45)




So DHT via multiple pathways increases nervous system strength, DHT increases epinephrine levels, decreases prolactin (assuming you have enough dopamine production as well), increases GABA, may decrease serotonin and serotonin receptors. All-round this means DHT has positive effects on your chemistry and nerve cells. By reducing prolactin, and estrogen, and subsequently serotonin, and also regulating catecholamines, by this, DHT can definitely increase libido, and alleviate sexual anxiety in most individuals by increasing GABA. DHT is key to many of Testosterone's brain benefits. Keep in mind though, despite positive effects on brain chemistry, this still doesn't give an excuse to OD on aromatase inhibitors, likely, because you need a little bit of estrogen (not much at all), to promote nNOS (neuronal nitric oxide synthase) production. So DHT serves as a great compliment to a little bit of brain estradiol, and a great ratio of DHT to estrogen means optimal sex drive, stamina, charisma and general masculinity.


Let's summarize in Bullets Here.


  • DHT regulates alpha and beta adrenergic receptors.
  • DHT may increase alpha-1-receptor density.
  • DHT may decrease glutamate activity and increases mGLU7 expression (which increases GABA release)
  • DHT increases serotonin 5-HT1A receptor density by influencing A1-Adr.Receptors.
  • DHT promotes serotonin 5-HT1A/1B activity and may reduce aggression in the presence of serotonin. Although this may easily be over ridden by the pro-adrenergic effects of DHT.
  • DHT increases beta-endorphin release by ^ 5-HT1A receptor indirect activation.
  • DHT facilitates the release of Epinephrine (adrenaline).
  • DHT increases cyclic AMP.
  • DHT blocks estrogen-induced prolactin release.
  • DHT reduces serotonin and serotonin receptors by inhibiting estrogen influence in the Brain. (but mainly acting to oppose 5-HT2A,2C and 5-HT4 receptors)
  • DHT increases Mitogen-Activated-Protein Kinase (MAPK) which leads to a variety of molecular changes and genomic changes as well as neural-changes; decreased serotonin activity in the brain and periphery.
  • DHT increases GABA and GABA-A (neurosteroid-specific) receptor expression.
  • DHT increases NMDA-receptors in the Hippocampus.
  • DHT increases Ca3 (Calcium) evoked Acetylcholine Function(AcH release).
  • DHT increases nervous system strength and regulates blood pressure.
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Oud 7 december 2021, 10:39   #158
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DHT restores anabolism / vitality / sexuality even in 90+ y.o. males​

A great study, a true blast from the (better) past, when androgenic steroids and especially DHT were not considered the devil reincarnate, but were commonly used for all types of ailments, including the broad physiological and psychological symptoms of aging such as sarcopenia (muscle loss), osteoporosis, senility, apathy/depression, and even sexual function. The study demonstrates that daily treatment with 25mg DHT (a.k.a Stanolone) was able to reverse most of these aging symptoms in a group of males with average age of 77+ years, and containing two subjects aged 83 and 93 years. Anybody who has met 90+ year-old (or even 80+ year-old) people is quite aware that such people have great difficulty moving, are often of poor mood and rarely have an interest in doing anything challenging/exciting - no doubt a result of their poor metabolic/energetic status and generalized frailty. Above all, such people are almost universally quite apathetic to the opposite sex and specifically to sexual activity. As the study demonstrates, DHT treatment not only greatly improved the muscle/bone/mood health but was able to reverse the "neuter attitude" quite common among such elderly males. If 25mg DHT daily can make 80-90 year-old males chase female nurses all day long, and get into fights out of jealousy - apparently, a medically-recognized sign of rejuvenation :- then the anti-aging industry is probably doomed as the humble DHT may have already solved their problem. Yes, that same DHT, which medicine tells us will make us bald, cancerous, and raging lunatics. Hhhmm, actually that last description fits quite well most male doctors I have met...and, of course, they do everything in their power to lower their endogenous DHT

Metabolism in the aged: the effect of stanolone on the retention of nitrogen, potassium, phosphorus, and calcium and on the urinary excretion of 17-keto, 11-oxy, and 17-hydroxy steroids in eight elderly men on high and low protein diets - PubMed
"...The stanolone used was suspended as microcrystals in a concentration of 50 mg./ml. sterile distilled water containing sodium carboxymethyl cellulose (0.1%) as a suspending agent, thimerosal (0.01%) as a preservative, and sodium chloride (0.9%). The steroid was administered intramuscularly in doses of 50 mg. on alternate days....A late result of hormone therapy was the change in mental attitude of the subjects. Joviality increased; testimonials of well-being were volunteered; generalized euphoria seemed to seize some; interest in the female sex was frequently expressed; evidences of jealousy over favors rendered by the female nursing staff developed, and a decided change from the customary neuter attitude of the patients toward the nurses became apparent."
"...The metabolic balance data indicate that stanolone is able to cause retention of the pro- toplasmic constituents of nitrogen, potassium, and phosphorus in men past 70 over and above the retention achieved by an adequate diet high in protein. When an isocaloric low protein diet was offered to the same indi- viduals, androgen therapy also resulted in re- tention of nitrogen, potassium, and phos- phorus, but to a quantitatively less extent than on the high protein regimen. Calcium retention was not produced by the hormone on either regimen. Data on urinary steroids revealed a significant increase in 17-keto- steroid excretion but no other changes. Side effects induced by the androgen used were primarily those of pain at the injection site, fluid retention, and increase in euphoria and libido."


---








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Oud 9 december 2021, 12:16   #159
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@ pionier

Wat je plaatste over ALS heeft me wel een beetje doen schrikken. Gebruik zelf nu ruim 4 jaar finasteride maar als finasteride daadwerkelijk de kans op die ziekte zou vergroten dan zou ik geen keus hebben en ermee moeten stoppen.

Vond over die studie dit bericht: https://alsnewstoday.com/news-posts/...tudy-suggests/

Leest iets makkelijker. Conclusie is inderdaad dat dht van belang zou zijn voor overleven neuronen. Patiënten met als bleken beduidend minder dht in de cerebrale vloeistof te hebben. Maar als dht zo'n belangrijke functie vervult, hoe zit dat dan met mensen die het helemaal niet aanmaken? Die mensen bestaan toch ook? En hoe zit het met vrouwen? Hebben zij evenveel dht als mannen?

Maar als dit klopt, en finasteride mogelijk tot als zou kunnen leiden, dan zou dat toch groot nieuws moeten zijn. Heb er nergens iets over kunnen vinden (en deze studie is alweer een jaar oud).
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Oud 9 december 2021, 12:34   #160
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Oke. Even gegoocheld. Dht levels tussen mannen, vrouwen en mannen die kalend zijn, zijn flink verschillend. https://pubmed.ncbi.nlm.nih.gov/1173...and%20December.

Vrouwen aanzienlijk minder dht. Denk dus niet dat het zo simpel is als: als je het aandeel dht aanzienlijk ndoet afnemen, dan verhoog je de kans op als. Als komt onder mannen meer voor dan vrouwen.
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Oud 10 januari 2022, 23:11   #161
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Ook zeer interessant om te weten is dat FDA gewoon toegeeft dat ze niet weten wat de lange termijn effecten zijn van finasteride:
Ja.. maar dat weten we/ze ook totaal niet van de anti coronavirus middelen die we 'allemaal' in ons lichaam hebben.
__________________
Huidig regime:

Revita shampoo
witte/groene thee
haar tabletten/Zink/Biotine
Minoxidil (9-11-2019 begonnen)
Foligain (5-9-2014 begonnen)
Dutasteride (26-08-2019 begonnen)
Fue 2000 Grafts (1-11-2019)

gestopt:


Propecia: (na 13 jaar gebruik)
Spectral.DNC-N (na 5 jaar gebruik)

Stand van zaken:
Zeer tevreden met huidige haar situatie.
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Oud 16 juni 2022, 23:32   #162
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Advances in Knowledge of Androgens: How Intentional and Accidental Neurosteroid Changes Inform Us of Their Action and Role



Synthesis of neurosteroids requires 5ɑ-R. As such, finasteride alters neurosteroid levels and can have robust effects clearly related to the adverse effects of finasteride that have been reported in men in the short term and long term following cessation of its use.


https://link.springer.com/article/10...30-020-00276-2






Goede site met updates over fina:


https://finasterideinfo.org/

Laatst gewijzigd door Pionier; 17 juni 2022 om 00:28
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Oud 7 november 2022, 11:05   #163
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https://www.pfsfoundation.org/news/a...lano-research/


Allopregnanolone Counteracts Finasteride-induced Alterations in Gut Microbiota, According to New University of Milano Research


Study marks first-ever demonstration of a successful PFS therapy in an animal model
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Oud 8 november 2022, 11:41   #164
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Volgens deze dokter zal minstens 1/3 van mannen die fina nemen bijwerkingen ervaren.


Ook een nieuwe reportage:



Laatst gewijzigd door Pionier; 8 november 2022 om 12:53
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Oud 17 november 2022, 09:15   #165
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Volgens deze dokter zal minstens 1/3 van mannen die fina nemen bijwerkingen ervaren.


Ook een nieuwe reportage:


Wat heftig zeg?? Ik was sowieso eerder van plan Minoxidil te gebruiken en hopelijk zijn de reacties daarop niet zo heftig!
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