Diclofenac 3% + Minox

[ryan82]

Ik heb iets nieuws gevonden, Diclofenac icm minox. Hieronder wat info + een link. Iemand interesse om hier mee ook te beginnen? Ik wil dit volgende maand proberen op een kalende plek bij mijn haarlijn.

Diclofenac 3% gel is a non-steroidal anti-inflammatory drug that inhibits COX-1 and COX-2 enzymes, resulting in decreased production of PGs and MMPs.'


Three male patients were visited in the dermatology department because of scalp AK, and received treatment with topical 3% diclofenac gel-based drug compound, once nightly for four to six months. One gram of the gel was used on a 10 × 10 cm area. All patients were in their seventies (73, 77 and 79 years old) and had also concomitant androgenetic alopecia for more than 15 years. During the follow-up visits after four and six months of starting the treatment, all patients and their families described terminal hair growth on non-prior haired areas of the scalp. This finding was also observed by the authors (Figures 1 and 2). There were neither relevant previous interventions nor concomitant medications that could interfere in the outcome. Patient 1 was followed-up for four years because of his AK, and showed continuous hair growth over the span of this period (Figure 1). Treatment was well tolerated in all cases and no adverse events were observed.

some terminal hair for the 3 seventies guys! topical application that targeted their AK areas not all their hair loss area, and just once a day for 6 months. After 4 years those terminal hair on the subject 1 continue to grow

I would love to know what kind of results we could see with 3% diclofenac once or twice a day, for more than 12 months, all over the balding areas and miniaturized hair ( even on the donor area), and on younger cases than the 3 seventies ( 2 recent studies showed how cells power decreased with age)"


http://webcache.googleusercontent.co...&ct=clnk&gl=fr

[Greven]

Ik heb het altijd een zéér interessante piste gevonden. In plaats van selectief PGD2 te gaan inhiberen (duur, moeilijk aan te geraken, veiligheid, zuiverheid,..) kun je makkelijker de volledige prostaglandine synthese inhiberen (goedkoper en betrouwbaarder). Maar dan moet je wel voldoende haarstimulerende prostaglandines (PGE1,PGE2,PGF2a) toedienen. De vraag zal zijn of minoxidil voldoende PGE1 effect zal geven voor de hergroei. En andere opmerking is de fotosensibiliteit van diclofenac op de huid aangezien daar toch veel zonlicht op zal komen.